What's a set that bombed for everyone but one person?

I was thinking about the night I did five minutes to a silent room except this one guy in the back who laughed at literally everything — the pauses, the half-jokes, even the sip of water. Everyone else just stared at their drinks. Do you remember a time you connected with exactly one person in an audience, or a conversation, while the rest of the room was dead? What does that even mean — were you bad, or were you just speaking to the wrong frequency in the room?